Synthesis Of Triethyl Ammonium Hydrobromide |
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| To a stirred, -78°C, 0.2M solution of N-tertbutyldimethylsilanyl-4-bromo
azetidinone in THF (0.5g, 1.894mM in 10ml), was added triethylamine
(0.26ml, 1.894mM). Thioacetic acid (0.14g, 1.894mM) was added dropwise
over 20 minutes forming a pale yellow solution, before the reaction mixture
was allowed to warm to ambient temperature over 2 hours and the solvent
removed by reduced pressure rotary evaporation. Ice cold diethyl ether
(25ml) was added with trituration causing precipitation of the product
as pale yellow crystals (0.32g, 93%, mp: 181-183°C). |
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