The total
synthesis of triethyl ammonium hydrobromide from expensive, difficult to
prepare starting materials.
Triethyl ammonium hydrobromide was synthesised in excellent yield from
N-tertbutyldimethylsilanyl-4-bromo azetidinone in a single step.
Experimental details
PH, UK |
pp 1-2 |
An easier and much more efficient method
for the drying of organic solvents.
We were interested by recent reports of the use of ovens for the drying
of solvents [J. Un. Chem, p163, 5 (2001)] but,
in our hands, these techniques resulted in disappointing yields and elevated
levels of capital expenditure. We report here an alternative method of
drying which involves reflux of solvents over mild drying agents such as
green paper towels or Kymwipes®.
RAK, UK |
pp 3-4 |
On the Classification
of Vigorous Reactions.
Did it go 'fizzle', 'phut', 'pop', 'bang' or 'kaboom'? A precisely
reproducible reference reaction is described which uses readily available
and inexpensive starting materials. By scaling the reaction logarithmically
from 10mg to 100g the above range of classifications can be encompassed,
bringing to an end any descriptive uncertainty. Workers in Nuclear Physics
may find scaling to 10¹¹kg of value, but probably just the once.
ST, UK |
pp 5-8 |
Total Synthesis of Prattleonamine Z, a
Selective Cytotoxic Marinated Aromatic Alkaloid when co-administered with
Sulfuric Acid.
We report herein the synthesis and biological evaluation of a novel
marinated aromantic alkaloid Prattleonamine Z. Preliminary in vitro
evaluation indicated that Prattleonamine Z possesses a distinct cytotoxicity
profile when co-administered with a molar excess of sulfuric acid. Sulfuric
acid on it's own demonstrated the most significant activity against all
cancer cell lines tested.
HM*, RK, UK |
pp 9-16 |
Iterative XEM: A Novel
Technique for Imaging of Single Protein-Protein Interactions.
Molecules are very, very small, and therefore require specialized instruments
for viewing. Conventional techniques such as laser confocal microscopy
and inverted fluorescence microscopy lack the resolution necessary for
visualization of individual enzyme-substrate interactions, which if possible
would enable directed synthesis of small molecule medicines and other drugs.
Here we demonstrate a novel technique, Iterative XEM (Xerox Enlargement
Microscopy), for use in optimizing resolution of existing data that may
allow nearly limitless magnification.
WCW, WA, USA |
pp 17-22 |
Decomposition studies using deuterated
chloroform.
It has been found that due to large numbers of overnight NMR experiments
running, compounds that can sit around for days unchanged will decompose
whilst waiting in an NMR queue. The original structure can then be deduced
from the new spectral data - i.e. that it was the desired compound, and
now isn't anymore. A graph of compound importance against likelihood the
NMR queue will be full shows a strong positive correlation.
HK, UK |
pp 23-26 |
Suppression of reaction
by omission of reagent: hydrogenation.
The reduction of olefins by medium pressure hydrogen in acetic acid
was completely suppressed by omission of 10% Pd on charcoal.
CCS |
pp 27-28 |
Suppression of reaction by omission of
reagent: oxidation.
Osmium catalysed dihydroxylation of olefins was suppressed by up to
95%, by omission of NMO.
CCS |
pp 29-30 |
Synthesis of Coal From
Vitamin B12.
CCS |
pp 31-32 |
Note: Drying of D2O.
We have found that while molecular sieves may be highly effective at
removing water from deuterated solvents such as CDCl3,
and d6 DMSO, they are suprisingly poor drying agents
for D2O.
CCS |
pp 33-34 |
